Intelligent food packaging with the multisensory analysis is promising as the next generation technology of food packaging. The oxygen content in food packaging is one of the crucial parameters affecting the food quality and shelf life. Caviar is among the most nutritious and costly food sources. Here, a photonic oxygen-sensing system, based on the time-resolved phosphorescence spectroscopy of a platinum complex, is developed for non-contact, non-intrusive, and real-time vacuum packaging quality control, and implemented for caviar packaging. The sensor is embedded in protective polyethylene layers and excited with a short-pulsed light emitting diode (LED) source. Integration of a blue pulsed light source, a fast and amplified silicon photodiode controlled by the Spartan-6 field programmable gate array (FPGA), and a long lifetime platinum complex results in a photonics-based oxygen sensor with a fast response and high sensitivity to the vacuum packaging damage, which is suitable for caviar. It is revealed that applying the polyethylene layers protects the caviar from the platinum complex, leaching while not interfering with the sensor functionality. Characterizing the photonic system based on its sensitivity, repeatability, stability, and long-term operation demonstrates its capability for this application.

提出了一种基于Co-四（4-羧苯基卟吩）（Co-TCPP）金属有机框架的马赫-曾德尔结构CO传感器。该传感结构在两段薄芯光纤以及薄芯光纤与单模光纤之间熔接粗锥，将Co-TCPP涂覆在薄芯光纤表面。Co-TCPP的纳米片状形貌和多孔微结构，使该传感器不仅易于与光纤粘附，还对CO有较强的吸附能力。通过X射线衍射、扫描电子显微镜、红外光谱、热重分析等表征分析敏感材料Co-TCPP的结构、形貌和性质。结果表明，该传感器对CO质量分数的灵敏度为0.0497 dB/10^-6，对质量分数-光强的拟合度高达0.99148，CO质量分数为40×10^-6时的响应时间约为120 s，且对CO具有良好的选择性和时间稳定性。

Atomic scale manufacturing is a necessity of the future to develop atomic scale devices with high precision. A different perspective of the quantum realm, which includes the tunnelling effect, leakage current at the atomic-scale, Coulomb blockade and Kondo effect, is inevitable for the fabrication and hence, the mass production of these devices. For these atomic-scale device development, molecular level devices must be fabricated. Proper theoretical studies could be an aid towards the experimental realities. Electronic transport studies are the basis to realise and interpret the problems happening at this minute scale. Keeping these in mind, we present a periodic energy decomposition analysis (pEDA) of two potential candidates for moletronics: phthalocyanines and porphyrins, by placing them over gold substrate cleaved at the (111) plane to study the adsorption and interaction at the interface and then, to study their application as a channel between two electrodes, thereby, providing a link between pEDA and electronic transport studies. pEDA provides information regarding the bond strength and the contribution of electrostatic energy, Pauli’s energy, orbital energy and the orbital interactions. Combining this analysis with electronic transport studies can provide novel directions for atomic/close-toatomic- scale manufacturing (ACSM). Literature survey shows that this is the first work which establishes a link between pEDA and electronic transport studies and a detailed pEDA study on the above stated molecules. The results show that among the molecules studied, porphyrins are more adsorbable over gold substrate and conducting across a molecular junction than phthalocyanines, even though both molecules show a similarity in adsorption and conduction when a terminal thiol linker is attached. A further observation establishes the importance of attractive terms, which includes interaction, orbital and electrostatic energies, in correlating the pEDA study with the transport properties. By progressing this research, further developments could be possible in atomic-scale manufacturing in the future.

The deposition of tetrakis (4-sulonatophenyl) porphyrin (TPPS) thin film on optical fibers presents many possibilities for sensing applications. The J-form aggregation with a narrow and sharp spectral feature at about 490 nm and its sensitivity to humidity have been discussed; a fast change of wavelength occurs according with variation in the humidity level. The reproducibility and high sensitivity of TPPS-coated fibers, along with the capabilities of optical fibers, suggest the device as a good candidate for humidity sensing in harsh environments.

使用喷涂法制备了四苯基卟啉锌(ZnTPP)薄膜及ZnTPP-单壁碳纳米管复合薄膜。 采用金相显微镜、 扫描电子显微镜、 台阶仪、 四探针测试仪、 紫外-可见光分光光度计、 傅里叶红外光谱仪对薄膜的形貌、 电学及光学性能等进行了系统的测量, 研究了ZnTPP薄膜及ZnTPP-碳纳米管复合薄膜的太赫兹响应特性。 结果表明, ZnTPP的太赫兹指纹谱峰为44, 57, 77, 88, 95和102 cm-1, 与文献[3]报道的棕树叶中叶绿素的指纹谱峰基本一致。 重要的是, 通过与碳纳米管相复合的方法, 不仅使ZnTPP有机薄膜的均匀性及致密性得到了改善, 还使后者的导电性及在紫外到太赫兹波段的光吸收性能获得明显增强。 此外, 还发现了复合薄膜在47及66 cm-1处出现新的太赫兹吸收峰, 证明了碳纳米管和ZnTPP之间存在的相互作用。 这种作用使复合薄膜的综合性能得到提高。 结果表明, 通过加入碳纳米管, 能够对ZnTPP的薄膜质量以及电学和光学性能等进行有效的改善, 使之具有综合优良的物理性能、 具备光电器件的应用前景。 研究成果对促进有机物的太赫兹光谱研究以及寻找新型太赫兹有机敏感材料等具有重要意义。

探讨了新型卟啉类光敏剂PA1介导的光动力抗菌(PACT)联合抗生素治疗重度创伤感染大鼠的效果并简要探讨其机制。健康雄性Wistar大白鼠24只(清洁级)作为实验对象，建立大面积创伤感染模型，随机分成模型对照组、PACT治疗组、抗生素治疗组、PACT联合抗生素治疗组，每组6只，共治疗8 d。检测不同时间点各组创面下的菌落数和创面愈合率，并采用酶联免疫吸附测定(ELISA)方法检测创面周边组织碱性成纤维因子(bFGF)、肿瘤坏死因子α(TNF-α)和白介素6(IL-6)的表达。结果表明PACT联合抗生素治疗与模型对照组相比能显著减轻大鼠创伤组织的炎症，减少创面组织中细菌的数量，加快创面愈合速率，缩短创面愈合时间；同时还能提高创面组织中bFGF的含量，抑制组织中炎症相关因子TNF-α和IL-6的表达，其效果优于单用PACT的治疗组和单用抗生素的治疗组。结果表明PACT联合抗生素可以治疗大面积创伤感染。

卟啉是一种潜在有效的光动力治疗癌症的光敏剂, 部分已用于临床实验中。 人血清蛋白(HSA)是药物的运输载体, 详细研究两者的相互作用对于阐述卟啉类药物的药代动力学行为具有重要的意义。 合成了一种新型水溶性羧酸锌(Ⅱ)卟啉配合物(2-Zn), 并通过紫外可见吸收光谱、 荧光光谱、 圆二色(CD)光谱和分子对接模拟研究了其与人血清蛋白(HSA)的相互作用。 结果表明: 2-Zn以静态猝灭的方式猝灭了HSA的内源荧光, 通过计算得到其与HSA在298和310 K下相互作用的猝灭常数分别为1.96×104和1.37×104 L·mol-1、 结合常数分别为1.93×104和1.50×104 L·mol-1、 结合位点数均为1, 两者间的结合作用力以静电作用为主, 同时也存在氢键和疏水作用。 位点竞争实验表明2-Zn主要结合在位点Ⅱ处; 根据Forster非辐射能量理论得到两者的结合距离和能量转移效率分别为4.01 nm和0.163。 紫外吸收光谱, 同步荧光和CD光谱显示2-Zn与HSA的相互作用影响了HSA 的构象, 表现为α-螺旋的含量降低; 分子对接模拟结果表明2-Zn通过疏水、 静电和氢键作用嵌入HSA分子的亚结构域IIIA(site Ⅱ)的疏水腔内, 与位点竞争实验和热力学判据所得的结果相一致。

光敏剂能否被肿瘤细胞高效吸收是影响光动力治疗效率的重要因素。亲脂性光敏剂易于被肿瘤组织摄取, 但会使光敏剂发生自猝灭; 亲水性光敏剂则有利于光敏剂在体内的转运, 但肿瘤细胞摄取率会下降。本工作通过亲酯性的乙二醇缩合支链和亲水性季膦基团与卟啉相连接, 成功制备一种新型两亲性卟啉锌化合物 (ZnTP-TP), 实验表明该化合物具有较高的单线态氧量子产率和良好的两亲性, 可被细胞快速摄取, 并表现出较低的细胞毒性和良好的肿瘤光动力治疗效应。