1 延边大学融合学院生物功能分子学, 吉林 延吉 133002
2 延边大学理学院化学系, 吉林 延吉 133002
3 延边大学化学国家级实验教学示范中心, 吉林 延吉 133002
空心硅酸锰纳米材料是一种新型无机材料, 其形貌主要包括空心纳米球、纳米颗粒、核壳结构等。其中空心硅酸锰纳米材料具有高比表面积、大孔容、可调的孔尺寸等特性, 同时具有良好的生物相容性和可降解性, 已被应用于生物、医药等领域。综述了空心硅酸锰及其复合纳米材料的合成方法, 主要包括水热法和沉淀法, 并对所合成的材料形貌和尺寸进行了总结, 介绍了其在癌症诊断、癌症治疗以及癌症的联合诊疗等方面的应用, 对今后硅酸锰纳米材料的研究重点和发展方向进行了展望。
空心硅酸锰 合成 磁共振成像 癌症诊断 癌症治疗 hollow manganese silicate synthesis magnetic resonance imaging cancer diagnosis cancer treatment
1 太原科技大学 应用科学学院, 山西 太原 030024
2 福建师范大学物理与能源学院 福建省量子调控与新能源材料重点实验室, 福建 福州 350117
3 山西医科大学 口腔医学院, 山西 太原 030051
碳点(CDs)作为一种新型的零维碳基纳米材料, 由于其优异的荧光性质、良好的生物兼容性、低细胞毒性以及丰富的表面官能团等性质, 在荧光传感和生物医学领域具有巨大的应用潜力。特别是针对肿瘤弱酸性的微环境特点, 设计pH响应型碳点来实现对肿瘤的特异性治疗将尤为重要。本文对近年来基于pH响应型碳点的研究工作进行了系统的调研, 综述了pH响应型碳点的荧光机制及其在pH传感、生物成像及癌症治疗等生物医学领域的应用, 并对pH响应型碳点目前面临的主要挑战以及未来发展的方向进行了展望。
pH响应型碳点 荧光机制 pH传感 生物成像 癌症治疗 pH-responsive carbon dots fluorescence mechanism pH sensing bioimaging cancer treatment
Author Affiliations
Abstract
1 RMIT Centre for Additive Manufacture, School of Engineering, RMIT University, Melbourne, Australia
2 Physical Sciences Department, Peter MacCallum Cancer Centre, Melbourne, Australia
3 ARC Industrial Transformation Training Centre in Additive Biomanufacturing, Queensland University of Technology, Brisbane, Australia
4 Centre for Medical Radiation Physics, University of Wollongong, Wollongong Australia
The additive manufacturing (AM) process plays an important role in enabling cross-disciplinary research in engineering and personalised medicine. Commercially available clinical tools currently utilised in radiotherapy are typically based on traditional manufacturing processes, often leading to non-conformal geometries, time-consuming manufacturing process and high costs. An emerging application explores the design and development of patient-specific clinical tools using AM to optimise treatment outcomes among cancer patients receiving radiation therapy. In this review, we: 1)? highlight the key advantages of AM in radiotherapy where rapid prototyping allows for patient-specific manufacture 2) explore common clinical workflows involving radiotherapy tools such as bolus, compensators, anthropomorphic phantoms, immobilisers, and brachytherapy moulds; 3) investigate how current AM processes are exploited by researchers to achieve patient tissuelike imaging and dose attenuations. Finally, significant AM research opportunities in this space are highlighted for their future advancements in radiotherapy for diagnostic and clinical research applications.
additive manufacturing radiotherapy tools dosimetry EBRT patient-specific cancer treatment quality assurance International Journal of Extreme Manufacturing
2020, 2(1): 012003
1 Department of Oncology, the First Affiliated Hospital of Chinese PLA General Hospital, Beijing 100048, China
2 Department of Engineering and Physics, University of Central Oklahoma, Edmond, Oklahoma 73034, USA
