单羟基咔咯的合成、晶体的生长和光动力抗菌活性研究

光动力抗菌疗法(PDAT)是一种新型的治疗微生物感染的手段, 咔咯在光动力抗肿瘤方面具有显著优势, 但在光动力抗菌方面却鲜有报道。本文合成了单羟基咔咯即10-(4-羟基苯基)-5, 15-二(2, 3, 4, 5, 6-五氟苯基)咔咯(P-OH), 并进一步研究其晶体结构和光动力抗菌活性。结果表明, 单羟基咔咯属于正交晶系, 具有良好的光动力抗菌活性, 药物浓度大于2MIC时其显示出杀菌作用, 药物浓度小于2MIC时其显示出抑菌作用, 其最低杀菌浓度和最低抑菌浓度皆比卟啉低, 是一种良好的光动力抗菌光敏剂。

Abstract

Photodynamic antimicrobial therapy (PDAT) is a new method for the treatment of microbial infections. However, there have been few reports on the photodynamic antimicrobial activity of corrole, which has a significant advantage in the treatment of photodynamic antitumor activity. In this study, mono-hydroxyl corrole named 10-(4-hydroxyphenyl)-5, 15-bis(pentafluorophenyl) corrole (P-OH) was synthesized. What’s more, its crystal structure and photodynamic antibacterial activity were also explored. The results indicate that mono-hydroxyl corrole belongs to orthorhombic crystal system and shows good photodynamic antibacterial activity. When the concentration of the drug is more than 2MIC, the bacteriostatic effect is showed. Whereas, the concentration of drug less than 2MIC shows antibacterial effect. The minimum bactericidal concentration and minimum inhibitory concentration of the drug are lower than porphyrin, it is a good photodynamic antibacterial photosensitizer.

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吴淑琼, 何裕良, 郑嘉琪, 黄婉瑜, 陈培妮, 莫晓琳, 叶嘉欣, 欧晓倩, 林佳颖, 郭惠琳, 黄慧琳, 许逸戈, 史蕾, 佘婷婷, 钟永辉. 单羟基咔咯的合成、晶体的生长和光动力抗菌活性研究[J]. 人工晶体学报, 2023, 52(3): 510. WU Shuqiong, HE Yuliang, ZHENG Jiaqi, HUANG Wanyu, CHEN Peini, MO Xiaolin, YE Jiaxin, OU Xiaoqian, LIN Jiaying, GUO Huilin, HUANG Huilin, XU Yige, SHI Lei, SHE Tingting, ZHONG Yonghui. Synthesis, Crystal Growth and Photodynamic Antibacterial Activity of Monohydroxy Corrole[J]. Journal of Synthetic Crystals, 2023, 52(3): 510.

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