低剂量激光处理促进神经干细胞增殖

吴晓蕾; 申琪; 邹争志

doi:doi:10.3969/j.issn.1007-7146.2018.05.004

激光生物学报, 2018, 27 (5): 407, 网络出版: 2018-11-25

低剂量激光处理促进神经干细胞增殖

Low-dose Laser Treatment Promotes Neural Stem Cell Proliferation

论文大纲

吴晓蕾申琪邹争志 ^*

作者单位

华南师范大学生物光子学研究院激光生命科学研究所暨激光生命科学教育部重点实验室, 广东广州 510631

低剂量激光处理神经干细胞阿尔兹海默症神经再生 low-level laser treatment neural stem cell Alzheimer’s disease neurogenesis

摘要

神经干细胞(neural stem cell, NSC)是脑内新生细胞的源泉, 周期性地在脑内两个重要区域分裂: 脑室和海马。当中枢神经系统(central nervous system, CNS)损伤后, 受损神经元胞外微环境含有大量阻止神经再生的因子, 导致神经干细胞增殖能力下降。低剂量激光处理(low-level laser treatment, LLLT)作为一种无损伤的新型物理疗法, 能调节机体的多种生物学功能, 为神经干细胞增殖提供一种潜在的治疗方法。我们研究发现低剂量弱激光处理可以促进小鼠海马区的神经干细胞增殖, 并且促进神经干细胞分化为新生的神经元, 这一研究可以成为神经再生的一种新手段, 将为低剂量激光处理治疗阿尔兹海默症在临床上的应用奠定基础。

Abstract

Neural Stem Cell(NSC)is the source of new cells in the brain, periodically dividing in two important regions of the brain:the ventricles and the hippocampus. When the central nervous system(CNS)is damaged, the damaged neurons release a large number of factors into the extracellular microenvironment and prevent neurogenesis, resulting in decreased proliferation of neural stem cells. Low-level laser treatment(LLLT), as a new physical therapy without damage, can regulate various biological functions of the body and provide a potential treatment for NSC proliferation. Our study found that LLLT can promote the proliferation of neural stem cells in the hippocampus of mice,and prompt NSC to differentiate into new neurons. Altogether,we show that LLLT can be a new treatment for neurogenesis. Moreover, we provide theory foundation for the clinical application of LLLT in Alzheimer’s disease.

参考文献

[1] ND M G, REYNOLDS B A, LAYWELL E D. Using the neurosphere assay to quantify neural stem cells in vivo［J］. Current Pharmaceutical Biotechnology, 2007, 8(3):141-145.

[2] GAO X, XING D. Molecular mechanisms of cell proliferation induced by low power laser irradiation［J］. Journal of Biomedical Science, 2009, 16(1):1-16.

[3] MENG C, HE Z, XING D. Low-level laser therapy rescues dendrite atrophy via upregulating bdnf expression:implications for alzheimer’s disease［J］. The Journal of Neuroscience, 2013, 33(33):13505-13517.

[4] HARDY J A, HIGGINS G A. Alzheimer’s disease:the amyloid cascade hypothesis［J］. Science, 1992, 256(5054):184-185.

[5] 申琪,王冠宇,刘镭.低功率激光照射缓解Aβ引起的神经细胞毒性［J］.激光生物学报, 2016, 25(06):515-518.

SHEN Qi, WANG Guanyu, LIU Lei. Attenuation of Aβ-induced neurotoxicity by low-power laser irradiation［J］. Acta Laser Biology Sinica, 2016, 25(06):515-518.

[6] 李婕,常好才,刘镭.高通量低功率激光诱发的凋亡肿瘤细胞激活树突状细胞［J］.激光生物学报, 2017, 26(06):495-499.

LI Jie, CHANG Haocai, LIU Lei. Cancer phototherapy activates antigen-presenting activity of dendritic cells［J］. Acta Laser Biology Sinica, 2017, 26(06):495-499.

[7] LUBART R, FRIEDMANN H, LEVINSHAL T, et al. Effect of light on calcium transport in bull sperm cells［J］. Journal of Photochemistry and Photobiology B, 1992, 15(4):337-341.

[8] LIANG J, LIU L, XING D. Photobiomodulation by low-power laser irradiation attenuates Aβ-induced cell apoptosis through the Akt/GSK3β/β-catenin pathway［J］. Free Radical Biology and Medicine, 2012, 53(7):1459-1467.

[9] KELLY D A, PIASECKI C, ANTHONY A, et al. Focal reduction of villous blood flow in early indomethacin enteropathy:a dynamic vascular study in the rat［J］.Gut, 1998, 42(3):366-373.

[10] HOND E D, PEETERS M, HIELE M, et al. Effect of long-term oral glutamine supplements on small intestinal permeability in patients with crohn’s disease ［J］.Journal of Parenteral and Enteral Nutrition, 1999, 13(5):679-685.

[11] BJARNASON I, HAYLL J, SMETHURST P, et al. Abnormal permeability precedes the development of a gluten sensitive enteropathy in Irish setter dogs［J］.Gut, 1991, 32(2):749-753.

[12] WENK G L. Neuropathologic changes in alzheimer’s disease［J］. Journal of Clinical, 2003, 64(Suppl 9): 7-10.

[13] FORSTL H, KURAZ A. Clinical features of alzheimer’s disease［J］. European Archives of Psychiatry and Clinical Neuroscience, 1999, 249(6):288-290.

[14] CARLESIMO G A, OSCAR-BERMAN M. Memory deficits in alzheimer’s patients:a comprehensive review［J］. Neuropsychol Review,1992, 3(2):119-169.

[15] TALER V, PHILLIPS N A. Language performance in alzheimer’s disease and mild cognitive impairment:a comparative review［J］. Journal of Clinical and Experimental Neuropsychology, 2008, 30(5):501-556.

[16] HASHIMOTO M, ROCKENSTEIN E L, CREWS E. Role of protein aggregation in mitochondrial dysfunction and neurodegeneration in alzheimer’s and parkinson’s diseases［J］. Neuromolecular Medicine, 2003, 4(1-2):21-36.

吴晓蕾, 申琪, 邹争志. 低剂量激光处理促进神经干细胞增殖[J]. 激光生物学报, 2018, 27(5): 407. WU Xiaolei, SHEN Qi, ZOU Zhengzhi. Low-dose Laser Treatment Promotes Neural Stem Cell Proliferation[J]. Acta Laser Biology Sinica, 2018, 27(5): 407.

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