中国激光, 2023, 50 (9): 0907105, 网络出版: 2023-04-25
基于OCT高精度定量的视网膜光生理功能成像技术 
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High‑Accuracy Quantitative Functional Imaging Technique for Retinal Opto‑Physiology with Optical Coherence Tomography
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图 1. 视网膜病变患者所见场景与视网膜结构。（a）正常视网膜与三种常见致盲性视网膜疾病的视觉表现；（b）视网膜的多层结构［3］
Fig. 1. Visual fields of patients with retinopathy and structure of retina. (a) Visual manifestations of normal retina and three common blinding retinal diseases; (b) multilayered structure of retina[3]
图 2. 功能信号在人眼视锥细胞和小鼠视杆细胞中的表现形式。（a）光刺激诱导的视锥细胞外段光程差改变及其在视网膜上的投影，刺激图案显示在左下角[50]；（b）方块状光刺激诱导的视锥细胞外段光程差改变及其（c）随刺激时间变化的测量结果[50]；（d）暗适应小鼠视网膜的OCT图像[51]；（e）经过光刺激之后2 min内小鼠视网膜线轮廓图的变化[51]；（f）3~5倍的视杆细胞外段散射增强[51]；（g）玻璃膜和巩膜的散射强度变化[51]；（h）外界膜和内/外段交接点处~2 μm的位置变化[51]
Fig. 2. Expressions of function signals in human cone and mouse rod photoreceptors. (a) Optical stimulus-induced cone outer segment optical path length change and its projection on retina enface with stimulus pattern shown in lower left inset[50]; (b) square-shape stimulus-induced cone outer segment optical path length change and (c) temporal measurement results[50]; (d) dark-adapted mouse retina OCT image[51]; (e) changes of retinal contour in mice within 2 min after light stimulation[51]; (f) 3-5 times scattering enhancement in rod outer segments[51]; (g) scattering changes of Bruch’s membrane and sclera[51]; (h) ~2 μm position changes of external limiting membrane and inner/outer segment junction[51]
图 3. 采用AO-OCT对人眼视锥细胞实现nm级的视觉光生理测量[61]。（a）利用AO-OCT相位信息检测暗适应视锥细胞在受到可见光刺激后外段长度的变化（∆OPL）；（b）视锥细胞图像；（c）视锥细胞对637 nm可见光刺激产生的响应；（d）根据∆OPL的强度视锥细胞被分为三类
Fig. 3. Nanoscale visual photophysiological measurements of individual cone cells in human eye by AO-OCT[61]. (a) Detecting outer segment optical path length change (∆OPL) of dark-adapted cone cell stimulated with visible flash using phase information by AO-OCT; (b) en face intensity image of cone mosaic; (c) responses of cone cells to 637 nm visible light stimulus; (d) classifying cone cells into three types according to intensity of ∆OPL
马艳红, 张鹏飞. 基于OCT高精度定量的视网膜光生理功能成像技术[J]. 中国激光, 2023, 50(9): 0907105. Yanhong Ma, Pengfei Zhang. High‑Accuracy Quantitative Functional Imaging Technique for Retinal Opto‑Physiology with Optical Coherence Tomography[J]. Chinese Journal of Lasers, 2023, 50(9): 0907105.
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