含矿物中成药及其胃肠消化液中五种重金属元素的测定研究

传统含雄黄中成药中可能含有多种微量元素及高含量的砷等有毒元素。对含雄黄的三种中成药分别采用微波消解与电热板消解进行处理, 用电感耦合等离子体质谱(ICP-MS）及电感耦合发射光谱(ICP-AES）法检测其中的As, Hg, Cu, Cd, Pb。此外, 还研究了含雄黄中成药经模拟人工胃肠消化后消化液中有毒有害金属含量。结果显示, 三种中成药中As, Hg, Cu, Cd, Pb总量变化范围分别为, As 24 350～68 627 mg·kg-1; Hg 0.26～122 313.6 mg·kg-1; Cu 2.04～6.95 mg·kg-1; Cd 0.02～1.46 mg·kg-1; Pb 0.42 ～40.60 mg·kg-1; 而人工胃肠消化液中含量分别为: As 81 ～ 618 mg·L-1; Hg 0.34～216 mg·L-1; Cu 1.08 ～ 2.15 mg·L-1; Cd和Pb未检出。上述结果为更加科学地评价中成药对人体健康的影响提供了数据基础。

Abstract

Chinese traditional medicine (CTM) containing realgar may contain high levels of toxic metals, such as arsenic, etc. The monitoring of trace elements, especially the harmful elements, is closely related to the quality control of the CTM. Three kinds of CTM containing realgar were digested by microwave method and electric heating plate method, and As, Hg, Cu, Cd and Pb were determined using ICP-MS and ICP-AES. In addition, this research determined the content of soluble heavy metals in the human gastrointestinal solution. The results showed that three kinds of CTM contained As of 24 350～68 627 mg·kg-1; Hg of 0.26～122 313.6 mg·kg-1; Cu of 2.04～6.95 mg·kg-1; Cd of 0.02～1.46 mg·kg-1; Pb of 0.42～40.60 mg·kg-1. In comparison, the contents of soluble heavy metals in the human gastrointestinal solution are: As of 81～618 mg·L-1; Hg of 0.34～216 mg·L-1; Cu of 1.08～215 mg·L-1, and Pb, Cd were not detected.

参考文献

[1] FU Jia-hua, ZHANG Wei-guo, LIU Li-ya(付家华, 张卫国, 刘利亚). Studies of Trace Elements and Health(微量元素与健康研究), 2004, 21(1): 40.

[2] LIU Jun-ling, GUO Zhen-xin(刘俊凌, 郭振欣). Studies of Trace Elements and Health(微量元素与健康研究), 2004, 21(3): 33.

[3] ZHANG Zhao-hua, JIA Cun-ying(张朝华, 贾存英). Studies of Trace Elements and Health(微量元素与健康研究), 2003, 20(1): 58.

[4] ZHANG Hua, WANG Ying-feng, SHI Yan-zhi, et al(张华, 王英锋, 施燕支, 等). Journal of Capital Normal University(Natural Science Edition)(首都师范大学学报·自然科学版), 2007, 28(3): 53.

[5] TANG Yi-shan, HUANG Zhi-yao, PAN Hua-xin, et al(汤毅珊, 黄志尧, 潘华新, 等). Traditional Chinese Drug Research & Clinical Pharmacology(中药新药与临床药理), 1999, 10(3): 177.

[6] LIANG Yao-hua, LIANG Guo-gang, ZHANG Ning-ning(梁曜华, 梁国刚, 张宁宁). China Journal of Chinese Materia Medicine(中国中药杂志), 2008, 33(19): 2273.

[7] Iris Koch, Steven Sylvester, Vivian W M Lai, et al. Toxicology and Applied Pharmacology, 2007, 222(3): 357.

[8] SUN Wei-min, XUE Da-fang, LI Hong, et al(孙卫民, 薛大方, 李红, 等). Spectroscopy and Spectral Analysis(光谱学与光谱分析), 2009, 29(1): 256.

[9] WANG Xiao-yin, LUO Jiang-yan, ZHANG Bei, et al(王筱寅, 罗江燕, 张蓓, 等). Journal of Chinese Medicinal Materials(中药材), 2009, 32(04): 631.

[10] Liu Jie, Lu Yuanfu, Wu Qin, et al. The Journal of Pharmacology and Experimental Therapeutics, 2008, 326(2): 363.

白国银, 韦超, 欧阳荔, 解清, 刘雅琼, 王军, 王京宇. 含矿物中成药及其胃肠消化液中五种重金属元素的测定研究[J]. 光谱学与光谱分析, 2011, 31(1): 256. BAI Guo-yin, WEI Chao, OUYANG Li, XIE Qing, LIU Ya-qiong, WANG Jun, WANG Jing-yu. Determination of 5 Heavy Metals in Chinese Traditional Medicines and Extraction Liquid Containing Mineral Materials[J]. Spectroscopy and Spectral Analysis, 2011, 31(1): 256.

含矿物中成药及其胃肠消化液中五种重金属元素的测定研究

关于本站 Cookie 的使用提示

全站搜索

含矿物中成药及其胃肠消化液中五种重金属元素的测定研究

相关论文

相关资讯

关于本站 Cookie 的使用提示

全站搜索