短波紫外线的消杀机制与影响因素 
下载： 615次
UVC Sterilization Mechanism and Influencing Factors
中国矿业大学（北京）化学与环境工程学院，北京 100083
图 & 表
图 1. 短波紫外线的消杀机制
Fig. 1. Elimination mechanism of UVC
下载图片 查看原文
图 2. 200~230 nm紫外线消杀机制
Fig. 2. Killing mechanism of 200–230 nm ultraviolet ray
下载图片 查看原文
图 3. 250~280 nm紫外线消杀机制图［11］
Fig. 3. Killing mechanism diagram of 250-280 nm ultraviolet rays[11]
下载图片 查看原文
图 4. 不同微生物的杀菌作用光谱
Fig. 4. Bactericidal spectra of different microorganisms
下载图片 查看原文
图 5. 紫外线辐照剂量与微生物灭活程度的关系图［41］
Fig. 5. Relationship between UV radiation dose and microbial inactivation degree[41]
下载图片 查看原文
图 6. 短波紫外线消杀安全性
Fig. 6. Sterilization safety of UVC
下载图片 查看原文
表 1紫外线的分类
Table1. Classification of ultraviolet rays
| Classification | Wavelength /nm |
|---|
| Long-wave UV（UVA） | 315-400 | | Medium-wave UV（UVB） | 280-315 | | Short-wave UV（UVC） | 200-280 | | Vacuum UV（VUV） | 100-200 |
|
查看原文
表 2短波紫外线的消杀机制
Table2. Elimination mechanism of UVC
| No. | Research subject | UV wavelength /nm | Elimination mechanism | Reference |
|---|
| 1 | Adenovirus | 210-290 | DNA damage at 240–290 nm is the main cause of microbial inactivation，and the presence of components other than DNA damage below 240 nm leads to microbial inactivation | ［13］ | | 2 | Bacillus alicyclic acid | 275 | DNA damage is the main cause of microbial inactivation | ［28］ | | 3 | Foodborne pathogens and yeasts | 266-279 | DNA damage is the main cause of microbial inactivation | ［29］ | | 4 | MHV-A59 virus | 254 | Protein damage accounts for 12% and genomic damage accounts for 88% | ［30］ | | 5 | SARS-CoV-2 | 253.7 | Genomic damage without damaging viral proteins | ［31］ | | 6 | Gram-positive and Gram-negative pathogenic bacteria | 222，254 | Sub-lethal damage from 254 nm low pressure mercury（LP Hg）lamp treatment is mainly due to DNA damage，while sub-lethal damage from 222 nm KrCl UV lamp treatment is due to membrane，enzyme，and DNA damage | ［6］ | | 7 | Salmonella Typhimurium and Lactobacillus monocytogenes | 280，222 | Cell membrane damage contributes to accelerated pathogen inactivation caused by combination therapy | ［32］ | | 8 | Foodborne pathogens | UVC and HClO | The mechanism of synergistic effects is related to membrane damage and，to a lesser extent，changes in membrane permeability | ［33］ | | 9 | Foodborne pathogens on the surface of cheese | 222 | The synergistic effect of outer membrane damage and lower photo-reactivation rate may cause an enhanced dissipative effect | ［10］ | | 10 | Adenovirus | 200-300 | Enhanced inactivation at low wavelengths correlates with adenovirus protein damage at these wavelengths | ［16］ | | 11 | E. coli O157：H7 | 222，282，and 254 | The higher elimination efficiency of 222 nm than 254 nm and 282 nm UV sources may be due to the damaged cell envelope | ［34］ |
|
查看原文
表 3短波紫外线在医疗方面上的应用
Table3. Short-wave UV for medical applications
| No. | Medical symptom | Whether it is better than traditional medical？ | Illumination time | Whether it it safe？ | Ref. |
|---|
| 1 | Herpes pharyngitis in children | Yes | Illumination 8-10 s | Yes | ［54］ | | 2 | Pediatric herpetic stomatitis | Yes | Once a day，4-6 s each time，for 5 d | Yes | ［55］ | | 3 | Mouth ulcers after chemotherapy for childhood leukemia | Yes | First irradiation 6 s，1 time per day | Yes | ［56］ | | 4 | Pediatric pneumonia | Yes | Increases with age，maximum time 5 s， | Yes | ［57］ | | 5 | Oral mucositis in hematopoietic stem cell transplant patients | Yes | 6 s for the first irradiation，1 s for each increment，1 time per day | Yes | ［58］ | | 6 | Post-burn residual wounds | Yes | Irradiation 20-30 s | Yes | ［59］ | | 7 | Radioactive oral mucositis | Yes | First treatment 1-10 s，increasing by 1 s day by day | Yes | ［60］ | | 8 | Acute drug phlebitis | Yes | Irradiation for 10-20 s，1 time per day | Yes | ［61］ | | 9 | Oral mucositis after chemotherapy for ovarian cancer | Yes | Illumination 5-10 s | | ［62］ | | 10 | Oral mucositis after hematopoietic stem cell transplantation | Yes | The first irradiation is 6 s，and each time increases by 1 s | | ［63］ | | 11 | Poor incision healing after cesarean section | Yes | Adjustment between 1 and 60 biological doses depending on the actual situation | | ［64］ | | 12 | Herpes zoster | Yes | Initial dose of 8-10 biological doses，followed by incremental increases of 20%-30% | | ［65］ |
|
查看原文
竹涛, 付顺江, 谢蔚, 徐欢. 短波紫外线的消杀机制与影响因素[J]. 中国激光, 2023, 50(9): 0907209. Tao Zhu, Shunjiang Fu, Wei Xie, Huan Xu. UVC Sterilization Mechanism and Influencing Factors[J]. Chinese Journal of Lasers, 2023, 50(9): 0907209.
PDF全文
